Toward a Tailored Acoustic-Based Approach in Music Neuromodulation in Epilepsy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F25%3A00082418" target="_blank" >RIV/00159816:_____/25:00082418 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/25:00141927 RIV/00216305:26220/26:0198293
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1111/ene.70151" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/ene.70151</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/ene.70151" target="_blank" >10.1111/ene.70151</a>
Alternative languages
Result language
angličtina
Original language name
Toward a Tailored Acoustic-Based Approach in Music Neuromodulation in Epilepsy
Original language description
BackgroundMusic-based neuromodulation has garnered interest as a potential therapeutic approach for drug-resistant epilepsy. This study expands on prior research by examining the effects of different musical features on interictal epileptiform discharges (IEDs) within intracerebral EEG (iEEG).MethodsTwenty-five patients with drug-resistant epilepsy undergoing presurgical iEEG evaluation participated in the study. Over 2 days, patients listened to various musical compositions characterized by distinct acoustic properties. EEG measurements were recorded before and after each listening session to evaluate IED changes.ResultsThe study identified individualized patterns in IED reduction, with certain acoustic properties showing consistent effects across musical genres. Mozart's "Piano Concerto No. 27" K 595c globally reduced IEDs by 28% while listening to music (p = 0.0191) and 19% in the postmusic resting state (p = 0.0111); relaxation music increased IEDs by 55% (p = 0.0197). Based on the acoustic analysis of individuals, we identified compositions that significantly reduced IEDs, with reductions ranging from 32% to 44% (p = 0.0001). In contrast, compositions with differing acoustic properties did not result in significant changes in IEDs. These results suggest that specific acoustic properties, rather than genre, primarily influence IEDs.ConclusionsThe findings suggest that specific acoustic properties can influence brain activity in a reproducible manner at the individual level, modulating IEDs based on personalized testing and selection across a spectrum of musical genres. These results suggest the potential for music-based neuromodulation as a personalized therapeutic approach in epilepsy management, emphasizing the importance of acoustic features over musical genre. Further research is needed to explore individual aspects of music-based interventions.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
<a href="/en/project/LX22NPO5107" target="_blank" >LX22NPO5107: National institute for Neurological Research</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Neurology
ISSN
1351-5101
e-ISSN
1468-1331
Volume of the periodical
32
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
"e70151"
UT code for WoS article
001546468300002
EID of the result in the Scopus database
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