Association of the IL-6R rs2228145 polymorphism with diabetic nephropathy: A case-control study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F25%3A00082481" target="_blank" >RIV/00159816:_____/25:00082481 - isvavai.cz</a>

Result on the web

<a href="https://onlinelibrary.wiley.com/doi/10.1111/jdi.70073" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/jdi.70073</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jdi.70073" target="_blank" >10.1111/jdi.70073</a>

Result language

angličtina

Original language name

Association of the IL-6R rs2228145 polymorphism with diabetic nephropathy: A case-control study

Original language description

Introduction: The pathogenesis of diabetes mellitus (DM) and its complications has been previously linked to elevated levels of interleukin-6 (IL-6); IL-6 triggers intracellular pathways through interaction with the IL-6 receptor (IL-6R). This study aimed to determine the association of single nucleotide polymorphisms (SNPs) IL-6 −597G/A (rs1800797), −572G/C (rs1800796), −174G/C (rs1800795), its receptor (IL-6R) Asp358Ala (+48892A/C, rs2228145) and DM or its complications in the Czech population. Materials and Methods: In total, 669 subjects participated in this case-control study, including 167 controls, 119 patients with type 1 DM (T1DM), and 383 patients with type 2 DM (T2DM). The subjects were monitored for glycemia, glycated hemoglobin, lipid profile, glomerular filtration rate (GFR), and common complications, such as diabetic nephropathy (DN), retinopathy (DR), (poly)neuropathy (DPN), and periodontitis (P). Results: Frequencies of the IL-6 and IL-6R alleles or genotypes, and IL-6 haplotypes were similar between the controls and the patients with T1DM or T2DM (P &gt; 0.05). However, lower values of GFR were observed in diabetic patients with IL-6 −174CC homozygotes compared to other (CG and GG) genotypes (P ≤ 0.05). In addition, the IL-6R Asp358Ala variant was associated with DN (P = 0.031, OR = 1.74, 95% CI: 1.05–2.89). After subclassification according to the type of DM, the significant association of the IL-6R polymorphism with DN was only found in T1DM (P = 0.013, OR = 2.90, 95% CI: 1.25–6.71). Conclusions: This study implies a significant relationship between the IL-6R Asp358Ala polymorphism and DN in Czech T1DM patients.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30102 - Immunology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Diabetes Investigation

ISSN

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e-ISSN

2040-1124

Volume of the periodical

16

Issue of the periodical within the volume

8

Country of publishing house

JP - JAPAN

Number of pages

10

Pages from-to

1463-1472

UT code for WoS article

001498475300001

EID of the result in the Scopus database

2-s2.0-105007027730