Post-Operative Atrial Fibrillation: Novel Predictive Value of CT-Derived Adipose Tissue Density in Minimally Invasive Mitral Surgery
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F25%3A00082577" target="_blank" >RIV/00159816:_____/25:00082577 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/25:00143237 RIV/61988987:17110/25:A2603DNO RIV/00216208:11120/25:43929521
Result on the web
<a href="https://www.biomed.cas.cz/physiolres/pdf/2025/74_S117.pdf" target="_blank" >https://www.biomed.cas.cz/physiolres/pdf/2025/74_S117.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.33549/physiolres.935754" target="_blank" >10.33549/physiolres.935754</a>
Alternative languages
Result language
angličtina
Original language name
Post-Operative Atrial Fibrillation: Novel Predictive Value of CT-Derived Adipose Tissue Density in Minimally Invasive Mitral Surgery
Original language description
Postoperative atrial fibrillation (POAF) remains a significant complication following minimally invasive thoracoscopic mitral valve surgery (MITMVS), yet current risk prediction models inadequately capture the underlying metabolic determinants of arrhythmogenesis. We investigated whether computed tomography (CT)-derived body composition parameters, as markers of metabolic status, could predict POAF risk in patients undergoing mitral valve repair. We retrospectively studied 104 consecutive MITMVS patients (2014-2023). Preoperative CT scans quantified skeletal muscle index, muscle density, and visceral/subcutaneous adipose tissue. Patients were grouped by preexisting atrial fibrillation (AF) with concurrent Maze (n=48) vs. no AF history (n=56). The primary outcome was POAF development. Higher visceral (VAT) and subcutaneous (SAT) adipose tissue density showed associations with increased POAF odds in multivariable analysis (VAT: OR 1.075, 95 % CI: 1.010;1.149, p=0.026; SAT: OR 1.073, 95 % CI: 1.011;1.146, p=0.025). Quartile analysis revealed a striking 5.5-fold increased POAF risk in the highest VAT density quartile compared to the lowest (42.3 % vs. 7.7 %). Notably, the relationship between intramuscular adipose tissue (IMAT) density and POAF differed between groups (interaction p=0.029), with a positive association in patients without prior AF (OR 1.167, 95 % CI: 1.011;1.377, p=0.047), but no significant relationship in those with preexisting AF (p=0.175). CT-derived tissue quality parameters, particularly VAT density, demonstrate robust associations with POAF risk following MITMVS. These findings establish preoperative CT-based metabolic assessment as a promising tool for perioperative risk stratification without additional testing burden.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physiological Research
ISSN
0862-8408
e-ISSN
1802-9973
Volume of the periodical
74
Issue of the periodical within the volume
S1
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
12
Pages from-to
"S117"-"S128"
UT code for WoS article
001690902000009
EID of the result in the Scopus database
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