Alendronate lowers cholesterol synthesis in the central nervous system of rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F09%3A00201710" target="_blank" >RIV/00179906:_____/09:00201710 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/09:00208714

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Alendronate lowers cholesterol synthesis in the central nervous system of rats

Original language description

Nitrogen-containing bisphosphonates were found to inhibit farnesyl diphosphate synthase - an essential enzyme in the cholesterol biosynthesis pathway, but their effect on cholesterol synthesis per se in the central nervous system (CNS) remained unknown.This study brings the first experimental evidence of the inhibition of cholesterol biosynthesis with alendronate in CNS of rats.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

58

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

4

Pages from-to

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UT code for WoS article

000268125600018

EID of the result in the Scopus database

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