Efficacy of Antipsychotic Drugs Against Hostility in the European First-Episode Schizophrenia Trial (EUFEST)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F11%3A10104340" target="_blank" >RIV/00179906:_____/11:10104340 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/11:10104340

Result on the web

<a href="http://www.ncbi.nlm.nih.gov/pubmed/21824456" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed/21824456</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4088/JCP.10m06529" target="_blank" >10.4088/JCP.10m06529</a>

Result language

angličtina

Original language name

Efficacy of Antipsychotic Drugs Against Hostility in the European First-Episode Schizophrenia Trial (EUFEST)

Original language description

Our objective was to compare the effects of haloperidol, amisulpride, olanzapine, quetiapine, and ziprasidone on hostility in first-episode schizophrenia, schizoaffective disorder, or schizophreniform disorder. We used the data acquired in the European First-Episode Schizophrenia Trial, conducted in 14 countries in 498 patients. The subjects joined the study as inpatients and continued with follow-up. The Positive and Negative Syndrome Scale (PANSS) was administered at baseline and at 1, 3, 6, 9, and 12months after randomization. We analyzed the scores on the PANSS hostility item in a subset of 302 patients showing at least minimal hostility (a score } 1) at baseline. We hypothesized (1) that the treatments would differ in their efficacy for hostilityand (2) that olanzapine would be superior to haloperidol. The primary analysis of hostility indicated an effect of differences between treatments (F(4,889) = 4.02, P = .0031). Post hoc treatment-group contrasts for hostility change showe

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FL - Psychiatry, sexology

OECD FORD branch

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Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Clinical Psychiatry

ISSN

0160-6689

e-ISSN

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Volume of the periodical

72

Issue of the periodical within the volume

7

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

955-961

UT code for WoS article

000293678600011

EID of the result in the Scopus database

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