Is rat liver affected by non-alcoholic steatosis more susceptible to the acute toxic effect of thioacetamide?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F11%3A10105385" target="_blank" >RIV/00179906:_____/11:10105385 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/11:10105385 RIV/00216275:25310/11:39892663
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2613.2011.00765.x/pdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2613.2011.00765.x/pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/j.1365-2613.2011.00765.x" target="_blank" >10.1111/j.1365-2613.2011.00765.x</a>
Alternative languages
Result language
angličtina
Original language name
Is rat liver affected by non-alcoholic steatosis more susceptible to the acute toxic effect of thioacetamide?
Original language description
There is only little evidence about altered sensitivity of steatotic liver to acute toxic injury. The aim of this project was to compare acute toxic effect of a model hepatotoxin thioacetamide (100 mg/ kg) on intact rat liver and rat liver affected by high-fat diet-induced non-alcoholic fatty liver disease (NAFLD). Serum biochemical parameters (ALT, AST, ALP, and bilirubin) and TNFalpha, hepatic IL-6 and TGFbeta1 and centrilobular necrosis with subsequent regenerative response of the liver were significantly higher in high-fat diet fed rats after thioacetamide administration. Steatotic rat liver, compared to non-steatotic liver, is more sensitive to acute toxic effect of thioacetamide.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GP305%2F08%2FP184" target="_blank" >GP305/08/P184: Is the liver affected by non-alcoholic liver disease (NAFLD) more sensitive to toxic injury?</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Experimental Pathology
ISSN
0959-9673
e-ISSN
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Volume of the periodical
92
Issue of the periodical within the volume
4
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
281-289
UT code for WoS article
000292331700008
EID of the result in the Scopus database
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