Susceptibility of rat non-alcoholic fatty liver to the acute toxic effect of acetaminophen

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F12%3A10125015" target="_blank" >RIV/00179906:_____/12:10125015 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/12:10125015
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1746.2011.06807.x/pdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1746.2011.06807.x/pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/j.1440-1746.2011.06807.x" target="_blank" >10.1111/j.1440-1746.2011.06807.x</a>

Result language
angličtina
Original language name
Susceptibility of rat non-alcoholic fatty liver to the acute toxic effect of acetaminophen
Original language description
Acetaminophen overdose is the most frequent cause of acute liver failure. Non-alcoholic fatty liver disease is the most common chronic condition of the liver. The aim was to assess whether non-alcoholic steatosis sensitizes rat liver to acute toxic effect of acetaminophen. Male Sprague-Dawley rats were fed a standard diet (ST-1, 10 % kcal fat) and high-fat gelled diet (HFGD, 71% kcal fat) for 6 weeks and then acetaminophen was applied in a single dose (1 g/kg body weight). Animals were killed 24, 48 and72 h after acetaminophen administration. Serum biochemistry, activities of mitochondrial complexes, hepatic malondialdehyde, reduced and oxidized glutathione, triacylglycerol and cholesterol contents, and concentrations of serum and liver cytokines (TNF-alpha, TGF-beta1) were measured and histopathological samples were prepared. The degree of liver inflammation and hepatocellular necrosis were significantly higher in HFGD fed animals after acetaminophen administration. Serum markers of
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
—

Project
<a href="/en/project/GP305%2F08%2FP184" target="_blank" >GP305/08/P184: Is the liver affected by non-alcoholic liver disease (NAFLD) more sensitive to toxic injury?</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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