The role of atorvastatin in bone metabolism in male albino Wistar rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F11%3A10105847" target="_blank" >RIV/00179906:_____/11:10105847 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/11:00002527 RIV/00216208:11150/11:10105847
Result on the web
<a href="http://dx.doi.org/10.1691/ph.2011.1525" target="_blank" >http://dx.doi.org/10.1691/ph.2011.1525</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1691/ph.2011.1525" target="_blank" >10.1691/ph.2011.1525</a>
Alternative languages
Result language
angličtina
Original language name
The role of atorvastatin in bone metabolism in male albino Wistar rats
Original language description
The aim of experiment was to follow the effect of atorvastatin on bone metabolism in male rats. Our study was carried out on 16 rats. The control group (CO) was given aqua pro injectione (0.2 mL/100 g BW; gavage) and the experimental group atorvastatin suspension (AT; 0.3mg in 0.2mL aqua pro inj./100 g BW; gavage) for 8 weeks. We examined serum markers of bone turnover using ELISA - C-terminal crosslinking telopeptide of type I collagen, osteocalcin, procollagen type I N propeptide and bone alkaline phosphatase (BALP). We investigated bone morphogenetic protein-2 (BMP-2) in the proximal tibia using Western blot analysis. We measured bone mineral density. The femurs were used for a biomechanical testing. After 8 weeks of atorvastatin administration, a significant decrease was found in serum level of BALP to 30% vs. CO (p = 0.005). The expression of BMP-2 was increased. Atorvastatin influenced bone metabolism by decreasing BALP, and probably in consequence increasing expression of BMP-2 in rats.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pharmazie
ISSN
0031-7144
e-ISSN
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Volume of the periodical
66
Issue of the periodical within the volume
8
Country of publishing house
DE - GERMANY
Number of pages
5
Pages from-to
606-610
UT code for WoS article
000294083100010
EID of the result in the Scopus database
2-s2.0-80053302438