Effects of amlodipine on bone metabolism in male albino Wistar rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F11%3A10124061" target="_blank" >RIV/00179906:_____/11:10124061 - isvavai.cz</a>

Alternative codes found

RIV/60162694:G44__/11:43874773 RIV/00216208:11150/11:10124061

Result on the web

<a href="http://actavet.vfu.cz/pdf/201180040391.pdf" target="_blank" >http://actavet.vfu.cz/pdf/201180040391.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2754/avb201180040391" target="_blank" >10.2754/avb201180040391</a>

Result language

angličtina

Original language name

Effects of amlodipine on bone metabolism in male albino Wistar rats

Original language description

The aim of our study was to investigate the effect of amlodipine on bone metabolism in male rats. Amlodipine (0.3 mg/100 g BW; gavage) was administered to 8 rats for 8 weeks. Control group (n=8) received aqua pro inj.. Bone marker concentrations of CTX-I and PINP in serum, and BALP in both serum and bone homogenate were measured by ELISA. We investigated expression of BMP-2 in tibia using Western blot, and bone mineral density was measured by DXA in lumbar and caudal vertebrae and in femoral areas. Femurs were used for biomechanical testing. After 8 weeks of amlodipine administration there was decrease in serum levels of BALP (p=0.0009) and CTX-I (p=0.003), and level of BALP in bone homogenate (p=0.026) compared to controls. Expression of BMP-2 was increased after amlodipine administration. Our findings suggest that amlodipine has retarding influence on bone metabolism in rats by decreasing bone turnover, which probably in consequence increases expression of BMP-2.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Veterinaria Brno

ISSN

0001-7213

e-ISSN

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Volume of the periodical

80

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

391-396

UT code for WoS article

000301811400012

EID of the result in the Scopus database

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