A comprehensive study of TP53 mutations in chronic lymphocytic leukemia: analysis of 1287 diagnostic and 1148 follow-up CLL samples

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F11%3A10106170" target="_blank" >RIV/00179906:_____/11:10106170 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/11:10106170

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S0145212610006120" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0145212610006120</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.leukres.2010.12.016" target="_blank" >10.1016/j.leukres.2010.12.016</a>

Result language

angličtina

Original language name

A comprehensive study of TP53 mutations in chronic lymphocytic leukemia: analysis of 1287 diagnostic and 1148 follow-up CLL samples

Original language description

TP53 plays a pivotal role in the process of DNA repair and apoptosis. In 10-20% of patients with chronic lymphocytic leukemia (CLL), the TP53 pathway is affected. In this study, we analyzed the TP53 mutation status in 2435 consecutive CLL samples, including 1287 diagnostic samples and 1148 samples during follow-up, using FASAY (Functional Analysis of Separated Alleles in Yeast) and direct sequencing. In a cohort of 1287 diagnostic CLL samples, we defined 237 cases with TP53 variants, including mutations, temperature-sensitive variants, deletions, insertions and aberrant splicing variants. In 1148 follow-up samples, no TP53 clonal evolution was observed.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

—

Project

—

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Leukemia Research

ISSN

0145-2126

e-ISSN

—

Volume of the periodical

35

Issue of the periodical within the volume

7

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

889-898

UT code for WoS article

000291470800028

EID of the result in the Scopus database

—