Quantification of ZAP-70 expression in chronic lymphocytic leukemia: T/B-cell ratio of mean fluorescence intensity provides stronger prognostic value than percentage of positive cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F11%3A10106195" target="_blank" >RIV/00179906:_____/11:10106195 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/11:10106195

Result on the web

<a href="http://www.ncbi.nlm.nih.gov/pubmed/21275464" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed/21275464</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/neo_2011_02_140" target="_blank" >10.4149/neo_2011_02_140</a>

Result language

angličtina

Original language name

Quantification of ZAP-70 expression in chronic lymphocytic leukemia: T/B-cell ratio of mean fluorescence intensity provides stronger prognostic value than percentage of positive cells

Original language description

Expression of ZAP-70 measured by flow cytometry belongs to the most powerful prognostic parameters in chronic lymphocytic leukemia (CLL). However, many technical factors such as setting of the positively treshold may significantly influence results. Quantification using mean fluorescent intensity (MFI) may eliminate the subjective error which is inevitable in the isotype control method. The aim of the present project was therefore to assess the prognostic significance of ZAP-70 using different methods.Our results suggest that measurement of ZAP-70 expression in CLL by MFI using T-cells/CLL cells ratio might be the optimal method for accurate prediction of clinical course. Combined analysis of ZAP-70 with CD38 or IgVH mutations status further refined individual patient''s prognosis.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neoplasma

ISSN

0028-2685

e-ISSN

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Volume of the periodical

58

Issue of the periodical within the volume

2

Country of publishing house

SK - SLOVAKIA

Number of pages

6

Pages from-to

140-145

UT code for WoS article

000290695700008

EID of the result in the Scopus database

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