Application of the comet assay method in clinical studies

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F11%3A10106378" target="_blank" >RIV/00179906:_____/11:10106378 - isvavai.cz</a>

Alternative codes found

RIV/60162694:G44__/11:00002574 RIV/00216208:11160/11:10106378

Result on the web

<a href="http://www.springerlink.com/content/37563j1456117247/fulltext.pdf" target="_blank" >http://www.springerlink.com/content/37563j1456117247/fulltext.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00508-011-0066-0" target="_blank" >10.1007/s00508-011-0066-0</a>

Result language

angličtina

Original language name

Application of the comet assay method in clinical studies

Original language description

The comet assay or single-cell gel electrophoresis (SCGE) assay is now widely accepted as a standard method for assessing DNA damage in individual cells.The comet assay should be eminently suitable for use in clinical practice since it is a relatively simple and inexpensive technique which requires only a few cells, and results can be obtained within a matter of hours.This method can be used in the study of cancer as well as in lifestyle and dietary studies. In cancer it is useful for measuring DNA damage before, throughout and after therapy (either radiotherapy or chemotherapy). Another use of this method is in lifestyle study, such as investigation of the effect on DNA of common human activities (e.g. smoking, or working with a potentially genotoxicagent). The final use of comet assay in this paper is dietary study. In this type of study we observe the effects of consumption of specific foods or supplements which may be protective for DNA against damage.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Wiener Klinische Wochenschrift

ISSN

0043-5325

e-ISSN

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Volume of the periodical

123

Issue of the periodical within the volume

23

Country of publishing house

DE - GERMANY

Number of pages

7

Pages from-to

693-699

UT code for WoS article

000298854400001

EID of the result in the Scopus database

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