Microheterogeneity of some serum glycoproteins in neurodegenerative diseases

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F12%3A10108107" target="_blank" >RIV/00179906:_____/12:10108107 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/12:10108107

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S0022510X11006587" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0022510X11006587</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jns.2011.11.006" target="_blank" >10.1016/j.jns.2011.11.006</a>

Result language

angličtina

Original language name

Microheterogeneity of some serum glycoproteins in neurodegenerative diseases

Original language description

Protein polymorphism and aberrant protein glycosylation may play important roles in human disorders, including neurodegenerative diseases. The aim of the study was to examine possible involvement of protein genetic variants and degree of glycosylation ofsome serum glycoproteins in the manifestation of neurodegenerative disorders in a Czech population sample. Apolipoprotein (Apo) E and three main serum markers of glycosylation defects (transferrin, Tf, alpha1-antitrypsin, aAT and ApoCIII) in patients with Alzheimer's dementia (AD), Parkinson disease (PD) and vascular dementia (n=62, 139 and 44, respectively) were analyzed by isoelectric focusing. Children with serious neurological symptoms (n=55) and three age-matched control groups (n=45, 45 and 42) were examined for comparison. Of the supposedly pathognomonic protein variants Tf C2, aAT ZM and ApoE e4 only the latter was detected with higher frequency in AD patients; significant synergy of the C2/e4 allelic combination was not confir

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FG - Paediatrics

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of the Neurological Sciences

ISSN

0022-510X

e-ISSN

—

Volume of the periodical

314

Issue of the periodical within the volume

1-2

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

6

Pages from-to

20-25

UT code for WoS article

000301273000004

EID of the result in the Scopus database

—