Identification of MicroRNAs associated with early relapse after nephrectomy in renal cell carcinoma patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F12%3A10125074" target="_blank" >RIV/00179906:_____/12:10125074 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/12:00060119 RIV/00216208:11150/12:10125074 RIV/00209805:_____/12:#0000373
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1002/gcc.21957/pdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/gcc.21957/pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/gcc.21957" target="_blank" >10.1002/gcc.21957</a>
Alternative languages
Result language
angličtina
Original language name
Identification of MicroRNAs associated with early relapse after nephrectomy in renal cell carcinoma patients
Original language description
Renal cell carcinoma (RCC) is the most common neoplasm of adult kidney. One of the important unmet medical needs in RCC is prognostic biomarker enabling identification of patients at high risk of relapse after nephrectomy. MicroRNAs (miRNAs) constitute arobust regulatory network with posttranscriptional regulatory efficiency for almost one-half of human coding genes, including oncogenes and tumor suppressors. To identify potential prognostic miRNAs, we analyzed expression profiles in tumors of different prognostic groups of RCC patients. Seventy-seven patients with clear cell RCC and detailed clinicopathological data were enrolled in a single-center study. Global miRNA expression profiles were obtained by use of TaqMan Low Density Arrays (754 parallelquantitative reverse-transcriptase polymerase chain reactions (qRT-PCR) reactions). For validation of identified miRNAs individual miRNA TaqMan assays were performed in an independent group of patients. We identified tumor relapse-signat
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Genes Chromosomes and Cancer
ISSN
1045-2257
e-ISSN
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Volume of the periodical
51
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
707-716
UT code for WoS article
000303762500008
EID of the result in the Scopus database
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