MiR-210 expression in tumor tissue and in vitro effects of its silencing in renal cell carcinoma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F13%3A33146555" target="_blank" >RIV/61989592:15110/13:33146555 - isvavai.cz</a>

Alternative codes found

RIV/00209805:_____/13:#0000471 RIV/00216208:11150/13:10193054 RIV/00179906:_____/13:10193054 RIV/00216224:14740/13:00065569

Result on the web

<a href="http://dx.doi.org/10.1007/s13277-012-0573-2" target="_blank" >http://dx.doi.org/10.1007/s13277-012-0573-2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s13277-012-0573-2" target="_blank" >10.1007/s13277-012-0573-2</a>

Result language

angličtina

Original language name

MiR-210 expression in tumor tissue and in vitro effects of its silencing in renal cell carcinoma

Original language description

Renal cell carcinoma (RCC) is the most common neoplasm of adult kidney accounting for about 3 % of adult malignancies. MicroRNAs (miRNAs) are a class of naturally occurring, short non-coding RNAs that regulate gene expression at the post-transcriptionallevel. We determined global miRNA expression profiles of RCC and parallel renal parenchyma tissues by using quantitative reverse transcriptase-polymerase chain reaction-based TaqMan low-density arrays. Afterward, we validated the difference in miR-210 expression levels on the larger group of RCC patients (35 RCC versus 10 non-tumorous parenchyma samples). Functional in vitro experiments were performed on ACHN and CAKI-2 RCC cell lines transfected with miRNA-210 inhibitor. Cell viability, apoptosis, cellcycle, scratch wound migration assay, and invasion assay (xCELLigence) were performed. We have identified original ccRCC-specific miRNA signature in clinical samples (73 miRNAs were significantly downregulated and five miRNAs upregulated

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Tumor biology

ISSN

1010-4283

e-ISSN

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Volume of the periodical

34

Issue of the periodical within the volume

1

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

11

Pages from-to

481-491

UT code for WoS article

000313875400056

EID of the result in the Scopus database

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