Genomic copy number variations: A breakthrough in our knowledge on schizophrenia etiology?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F12%3A10125574" target="_blank" >RIV/00179906:_____/12:10125574 - isvavai.cz</a>

Alternative codes found

RIV/61988987:17110/12:A13017K4 RIV/00216208:11150/12:10125574 RIV/00843989:_____/12:00102868

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Genomic copy number variations: A breakthrough in our knowledge on schizophrenia etiology?

Original language description

OBJECTIVES: The term "copy number variation/variant" (CNV) denotes a DNA sequence with a magnitude of 1 kb at least which is differently represented among individuals based on its deletion or duplication. Since 2008, multiple studies have reported copy number variations in schizophrenia, and they seem to fill in a gap in our knowledge on the genetic background of schizophrenia. The aim of this review is to sum up the current findings related to CNVs in schizophrenia in order to facilitate further research. METHODS: We searched the PubMed computer database using the key words "schizophrenia AND CNVs" on 26th October 2011. Out of 91 obtained results, we selected the references based on their relevance. RESULTS: The CNVs at genome loci 1q21.1, 2p16.3, 3q29, 15q11.2, 15q13.3, 16p13.1 and 22q11.2 were associated with schizophrenia most frequently. The data provide evidence for low prevalent, but highly penetrant CNVs associated with schizophrenia. CNV deletions show higher penetrance than d

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FL - Psychiatry, sexology

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

—

Volume of the periodical

33

Issue of the periodical within the volume

2

Country of publishing house

SE - SWEDEN

Number of pages

8

Pages from-to

183-190

UT code for WoS article

000305037700012

EID of the result in the Scopus database

—