In Vitro Antibacterial and Antifungal Activity of Salicylanilide Pyrazine-2-carboxylates
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F12%3A10128912" target="_blank" >RIV/00179906:_____/12:10128912 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/12:10128912 RIV/00216208:11160/12:10128912
Result on the web
<a href="http://www.ingentaconnect.com/content/ben/mc/2012/00000008/00000004/art00028" target="_blank" >http://www.ingentaconnect.com/content/ben/mc/2012/00000008/00000004/art00028</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/157340612801216346" target="_blank" >10.2174/157340612801216346</a>
Alternative languages
Result language
angličtina
Original language name
In Vitro Antibacterial and Antifungal Activity of Salicylanilide Pyrazine-2-carboxylates
Original language description
The development of new antimicrobial agents for the treatment of infectious diseases remains challenging due to the increasing impact of antibiotic resistance. Since salicylanilides and esters of pyrazine-2-carboxylic acid have been described as potential antimicrobials, we have designed and synthesized a series of 2-(phenylcarbamoyl) phenyl pyrazine-2-carboxylates. These were evaluated in vitro for the activity against fungi and Gram-positive and Gram-negative bacteria. All derivatives showed significant antibacterial activity against Gram-positive strains (MIC }= 0.98 mu mol/L) including methicillin-resistant Staphylococcus aureus. The most active molecule was 5-chloro-2-(3-chlorophenylcarbamoyl) phenyl pyrazine-2-carboxylate. With one exception these esters were at least partly active against fungi tested strains, in particular against mould strains (MIC }= 1.95 mu mol/L). The most active antifungal agent overall proved to be 2-(4-bromophenylcarbamoyl)-4-chlorophenyl pyrazine-2-carboxylate.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
<a href="/en/project/NS10367" target="_blank" >NS10367: Evaluation and development of new perspective antimycobacterial drugs and prodrugs active against multidrug resistant strains</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Medicinal Chemistry
ISSN
1573-4064
e-ISSN
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Volume of the periodical
8
Issue of the periodical within the volume
4
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
732-741
UT code for WoS article
000309524600028
EID of the result in the Scopus database
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