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In Vitro Antibacterial and Antifungal Activity of Salicylanilide Benzoates

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F12%3A10124293" target="_blank" >RIV/00179906:_____/12:10124293 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11150/12:10124293 RIV/00216208:11160/12:10124293

  • Result on the web

    <a href="http://www.tswj.com/2012/290628/" target="_blank" >http://www.tswj.com/2012/290628/</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1100/2012/290628" target="_blank" >10.1100/2012/290628</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    In Vitro Antibacterial and Antifungal Activity of Salicylanilide Benzoates

  • Original language description

    The resistance to antimicrobial agents brings a need of novel antimicrobial agents. We have synthesized and found the in vitro antibacterial activity of salicylanilide esters with benzoic acid (2-(phenylcarbamoyl) phenyl benzoates) in micromolar range. They were evaluated in vitro for the activity against eight fungal and eight bacterial species. All derivatives showed a significant antibacterial activity against Gram-positive strains with minimum inhibitory concentrations }= 0.98 mu mol/L including methicillin-resistant Staphylococcus aureus strain. The most active compounds were 5-chloro-2-(3,4-dichlorophenylcarbamoyl) phenyl benzoate and 4-chloro-2-(4-(trifluoromethyl) phenylcarbamoyl) phenyl benzoate. The antifungal activity is significantly lower.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10401 - Organic chemistry

Result continuities

  • Project

    <a href="/en/project/NS10367" target="_blank" >NS10367: Evaluation and development of new perspective antimycobacterial drugs and prodrugs active against multidrug resistant strains</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    The Scientific World Journal

  • ISSN

    1537-744X

  • e-ISSN

  • Volume of the periodical

    2012

  • Issue of the periodical within the volume

    2012

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    7

  • Pages from-to

  • UT code for WoS article

    000304801900001

  • EID of the result in the Scopus database