In Vitro Antibacterial and Antifungal Activity of Salicylanilide Benzoates
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F12%3A10124293" target="_blank" >RIV/00179906:_____/12:10124293 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/12:10124293 RIV/00216208:11160/12:10124293
Result on the web
<a href="http://www.tswj.com/2012/290628/" target="_blank" >http://www.tswj.com/2012/290628/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1100/2012/290628" target="_blank" >10.1100/2012/290628</a>
Alternative languages
Result language
angličtina
Original language name
In Vitro Antibacterial and Antifungal Activity of Salicylanilide Benzoates
Original language description
The resistance to antimicrobial agents brings a need of novel antimicrobial agents. We have synthesized and found the in vitro antibacterial activity of salicylanilide esters with benzoic acid (2-(phenylcarbamoyl) phenyl benzoates) in micromolar range. They were evaluated in vitro for the activity against eight fungal and eight bacterial species. All derivatives showed a significant antibacterial activity against Gram-positive strains with minimum inhibitory concentrations }= 0.98 mu mol/L including methicillin-resistant Staphylococcus aureus strain. The most active compounds were 5-chloro-2-(3,4-dichlorophenylcarbamoyl) phenyl benzoate and 4-chloro-2-(4-(trifluoromethyl) phenylcarbamoyl) phenyl benzoate. The antifungal activity is significantly lower.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
<a href="/en/project/NS10367" target="_blank" >NS10367: Evaluation and development of new perspective antimycobacterial drugs and prodrugs active against multidrug resistant strains</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
The Scientific World Journal
ISSN
1537-744X
e-ISSN
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Volume of the periodical
2012
Issue of the periodical within the volume
2012
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
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UT code for WoS article
000304801900001
EID of the result in the Scopus database
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