Monitoring trough voriconazole plasma concentrations in haematological patients: real life multicentre experience

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F12%3A10129300" target="_blank" >RIV/00179906:_____/12:10129300 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/12:10129300 RIV/00023736:_____/12:00009607 RIV/00216224:14110/12:00074593

Result on the web

<a href="http://dx.doi.org/10.1111/j.1439-0507.2012.02186.x" target="_blank" >http://dx.doi.org/10.1111/j.1439-0507.2012.02186.x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/j.1439-0507.2012.02186.x" target="_blank" >10.1111/j.1439-0507.2012.02186.x</a>

Result language

angličtina

Original language name

Monitoring trough voriconazole plasma concentrations in haematological patients: real life multicentre experience

Original language description

The objective of this retrospective study was to evaluate results from voriconazole therapeutic drug monitoring (TDM) in haematological patients in routine clinical practice. Between 2005 and 2010, 1228 blood samples were obtained from 264 haematologicalpatients (median 3 samples/patient; range 127) receiving voriconazole for targeted/preemptive treatment of invasive aspergillosis (IA) (46.3% of samples), empirical therapy (12.9%) or prophylaxis (40.8%). A high-pressure liquid chromatography assay wasused to analyse voriconazole concentrations. Clinical and laboratory data were analysed retrospectively. The median of the detected voriconazole plasma concentration was 1.00 mu g ml-1 (range <0.2013.47 mu g ml-1). Significant inter- and intra-patients variability of measured concentrations (81.9% and 50.5%) were identified. With the exception of omeprazole administration, there was no relevant relationship between measured voriconazole concentrations and drug dose, route administration,

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Mycoses

ISSN

0933-7407

e-ISSN

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Volume of the periodical

55

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

483-492

UT code for WoS article

000309888700003

EID of the result in the Scopus database

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