Monitoring through voriconazole plasma concentrations in haematological patients: real life multicentre experience
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F12%3A%230001663" target="_blank" >RIV/65269705:_____/12:#0001663 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/j.1439-0507.2012.02186.x" target="_blank" >http://dx.doi.org/10.1111/j.1439-0507.2012.02186.x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/j.1439-0507.2012.02186.x" target="_blank" >10.1111/j.1439-0507.2012.02186.x</a>
Alternative languages
Result language
angličtina
Original language name
Monitoring through voriconazole plasma concentrations in haematological patients: real life multicentre experience
Original language description
The objective of this retrospective study was to evaluate results from voriconazole therapeutic drug monitoring (TDM) in haematological patients in routine clinical practice. Between 2005 and 2010, 1228 blood samples were obtained from 264 haematologicalpatients receiving voriconazole for targeted/preemptive treatment of invasive aspergillosis (IA), empirical therapy or prophylaxis. A high-pressure liquid chromatography assay was used to analyse voriconazole concentrations. Clinical and laboratory datawere analysed retrospectively. With the exception of omeprazole administration, there was no relevant relationship between measured voriconazole concentrations and drug dose, route administration, age, gender, CYP2C19*2 genotype, gastrointestinal tractabnormality, administration via nasogastric tube, serum creatinine, and liver enzymes. However, per patient analysis identified significant role of individual voriconazole dose and drug form change on measured plasma concentration. Measur
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mycoses
ISSN
0933-7407
e-ISSN
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Volume of the periodical
55
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
483-492
UT code for WoS article
000309888700003
EID of the result in the Scopus database
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