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Monitoring through voriconazole plasma concentrations in haematological patients: real life multicentre experience

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F12%3A%230001663" target="_blank" >RIV/65269705:_____/12:#0001663 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1111/j.1439-0507.2012.02186.x" target="_blank" >http://dx.doi.org/10.1111/j.1439-0507.2012.02186.x</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/j.1439-0507.2012.02186.x" target="_blank" >10.1111/j.1439-0507.2012.02186.x</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Monitoring through voriconazole plasma concentrations in haematological patients: real life multicentre experience

  • Original language description

    The objective of this retrospective study was to evaluate results from voriconazole therapeutic drug monitoring (TDM) in haematological patients in routine clinical practice. Between 2005 and 2010, 1228 blood samples were obtained from 264 haematologicalpatients receiving voriconazole for targeted/preemptive treatment of invasive aspergillosis (IA), empirical therapy or prophylaxis. A high-pressure liquid chromatography assay was used to analyse voriconazole concentrations. Clinical and laboratory datawere analysed retrospectively. With the exception of omeprazole administration, there was no relevant relationship between measured voriconazole concentrations and drug dose, route administration, age, gender, CYP2C19*2 genotype, gastrointestinal tractabnormality, administration via nasogastric tube, serum creatinine, and liver enzymes. However, per patient analysis identified significant role of individual voriconazole dose and drug form change on measured plasma concentration. Measur

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Mycoses

  • ISSN

    0933-7407

  • e-ISSN

  • Volume of the periodical

    55

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    10

  • Pages from-to

    483-492

  • UT code for WoS article

    000309888700003

  • EID of the result in the Scopus database