Identification and functional screening of microRNAs highly deregulated in colorectal cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F12%3A10129317" target="_blank" >RIV/00179906:_____/12:10129317 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14740/12:00059697 RIV/00209805:_____/12:#0000340 RIV/00216208:11150/12:10129317

Result on the web

<a href="http://dx.doi.org/10.1111/j.1582-4934.2012.01579.x" target="_blank" >http://dx.doi.org/10.1111/j.1582-4934.2012.01579.x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/j.1582-4934.2012.01579.x" target="_blank" >10.1111/j.1582-4934.2012.01579.x</a>

Result language

angličtina

Original language name

Identification and functional screening of microRNAs highly deregulated in colorectal cancer

Original language description

MicroRNAs (miRNAs) constitute a robust regulatory network with post-transcriptional regulatory efficiency for almost one half of human coding genes, including oncogenes and tumour suppressors. We determined the expression profile of 667 miRNAs in colorectal cancer (CRC) tissues and paired non-tumoural tissues and identified 42 differentially expressed miRNAs. We chose miR-215, miR-375, miR-378, miR-422a and miR-135b for further validation on an independent cohort of 125 clinically characterized CRC patients and for in vitro analyses. MiR-215, miR-375, miR-378 and miR-422a were significantly decreased, whereas miR-135b was increased in CRC tumour tissues. Levels of miR-215 and miR-422a correlated with clinical stage. MiR-135b was associated with higherpre-operative serum levels of CEA and CA19-9. In vitro analyses showed that ectopic expression of miR-215 decreases viability and migration, increases apoptosis and promotes cell cycle arrest in DLD-1 and HCT-116 colon cancer cell lines.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Cellular and Molecular Medicine

ISSN

1582-1838

e-ISSN

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Volume of the periodical

16

Issue of the periodical within the volume

11

Country of publishing house

RO - ROMANIA

Number of pages

12

Pages from-to

2655-2666

UT code for WoS article

000310555200010

EID of the result in the Scopus database

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