Time-dependent changes of oxime K027 concentrations in different parts of rat central nervous system
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F13%3A10132976" target="_blank" >RIV/00179906:_____/13:10132976 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/13:43874761 RIV/62690094:18470/13:50001174
Result on the web
<a href="http://link.springer.com/article/10.1007%2Fs12640-012-9329-4#page-1" target="_blank" >http://link.springer.com/article/10.1007%2Fs12640-012-9329-4#page-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s12640-012-9329-4" target="_blank" >10.1007/s12640-012-9329-4</a>
Alternative languages
Result language
angličtina
Original language name
Time-dependent changes of oxime K027 concentrations in different parts of rat central nervous system
Original language description
The blood-brain barrier plays a vital role in the protection of the central nervous system. It is composed of endothelial cells with tight-junctions to limit the penetration of many endogenous and exogenous compounds, particularly hydrophilic xenobiotics. Nerve agents and pesticides are groups of compounds with high penetration potential into the central nervous system. However, oxime type antidotes are known to penetrate blood-brain barrier only in low concentration. The aim of presented study is to describe the pharmacokinetic profile of oxime K027 a novel antidote candidate. The main focus is on penetration of tested substance into the selected brain regions following time-dependent manner. The maximum concentration of the oxime K027 was attaining 15 and 30 min after i.m. application in plasma and brain tissue, respectively. The perfused brain tissue concentration was relatively high (10(-7) M order of magnitude) and depending on the brain region it was constant 15-60 min after appl
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ME09086" target="_blank" >ME09086: Development of novel antidotal treatment against organophosphorus pesticides</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neurotoxicity Research
ISSN
1029-8428
e-ISSN
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Volume of the periodical
23
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
63-68
UT code for WoS article
000312664800005
EID of the result in the Scopus database
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