Entry of oxime K027 into the different parts of rat brain: Comparison with obidoxime and oxime HI-6

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10190527" target="_blank" >RIV/00179906:_____/14:10190527 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/14:43875081
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S1214021X13000069#" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1214021X13000069#</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jab.2013.01.001" target="_blank" >10.1016/j.jab.2013.01.001</a>

Result language
angličtina
Original language name
Entry of oxime K027 into the different parts of rat brain: Comparison with obidoxime and oxime HI-6
Original language description
Acetylcholinesterase reactivators (oximes) are highly hydrophilic compounds. This factor is considered to limit their distribution through the human body, especially into the central nervous system. However, some results contradict this hypothesis and confirm low concentrations of oximes inside the CNS. This study aims to verify oxime penetration through the blood-brain barrier, and into different brain regions. It has been confirmed that oximes can penetrate the BBB after therapeutic dose administration (0.73%, 0.69%, and 0.52% corresponding to obidoxime, HI-6, and new oxime K027). Although the whole brain level of K027 seems to be lower compared with other oximes we have to keep in mind that these numbers represent only a percentage of the concentration found in plasma. So, for more adequate comparison it is essential to have a look at the actual concentration of oximes in the wet brain tissue: 106.6 19.87 ng/g (K027), 49.88 10.21 ng/g (obidoxime) and 86.51 42.37 ng/g (HI-6), where c
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
<a href="/en/project/NT12062" target="_blank" >NT12062: Preparation and biological evaluation of new therapeutics against to pesticides</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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