Acetylcholinesterase inhibitors used or tested in Alzheimer's disease therapy; their passive diffusion through blood brain barrier: In vitro study

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F13%3A10145974" target="_blank" >RIV/00179906:_____/13:10145974 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/13:43874855
Result on the web
<a href="http://www.academicjournals.org/article/article1380887808_Karasova%20et%20al.pdf" target="_blank" >http://www.academicjournals.org/article/article1380887808_Karasova%20et%20al.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5897/AJPP2013.2977" target="_blank" >10.5897/AJPP2013.2977</a>

Result language
angličtina
Original language name
Acetylcholinesterase inhibitors used or tested in Alzheimer's disease therapy; their passive diffusion through blood brain barrier: In vitro study
Original language description
Although the information about Alzheimer's disease (AD) etiology is still unclear; acetylcholinesterase inhibitors still play a major role in symptomatic treatment of AD. Unfortunately, a relevant argumentation is complicated since information about realdrug concentration in the brain or timedependent blood-brain barrier (BBB) distribution studies are still quite rare. In this in vitro study, highperformance liquid chromatography (HPLC) method with special (IAM - immobilized artificial membrane) columnwas used to determine the ability of cholinesterase inhibitors to penetrate through BBB. Set of 8 structurally different cholinesterase inhibitors applicable to AD treatment was evaluated throughout this study. According to our method, all molecules areable to penetrate BBB by passive transport. However, some molecules such as huperzine A and galanthamine have lower ability to penetrate the BBB directly. These molecules may be delivered into the brain via active transport. Other molecu
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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