In vitro screening of blood-brain barrier penetration of mnoquaternary acetylcholinesterase reactivators
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F10%3A00002414" target="_blank" >RIV/60162694:G44__/10:00002414 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
In vitro screening of blood-brain barrier penetration of mnoquaternary acetylcholinesterase reactivators
Original language description
HPLC method for prediction of drug penetration into the CNS was examined in our study. In this in vitro study, we determinated the ability of monoquaternary AChE reactivators to penetrate through blood-brain barrier (BBB). As resulted, the position of the oxime group on the pyridine ring plays a role for penetration of oximes into brain.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NS9748" target="_blank" >NS9748: The Evaluation of Penetration of Different Acetylcholinesterase Reactivators through Blood-Brain Barrier</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Analytical Letters
ISSN
0003-2719
e-ISSN
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Volume of the periodical
43
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
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UT code for WoS article
000278775700009
EID of the result in the Scopus database
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