A comparison of decontamination effects of commercially available detergents in rats pre-exposed to topical sulphur mustard

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F13%3A10159526" target="_blank" >RIV/00179906:_____/13:10159526 - isvavai.cz</a>

Alternative codes found

RIV/60162694:G44__/13:43874675

Result on the web

<a href="http://informahealthcare.com/doi/abs/10.3109/15569527.2012.730087" target="_blank" >http://informahealthcare.com/doi/abs/10.3109/15569527.2012.730087</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3109/15569527.2012.730087" target="_blank" >10.3109/15569527.2012.730087</a>

Result language

angličtina

Original language name

A comparison of decontamination effects of commercially available detergents in rats pre-exposed to topical sulphur mustard

Original language description

Objective: The genotoxic vesicant sulphur mustard [bis-2-(chloroethyl)sulphide] is a chemical warfare agent which is easily available due to its relatively simple synthesis. Thus, sulphur mustard is a potential agent for mass contamination. In this study, we focused on sulphur mustard toxicity and decontamination in a rat model using commercially available detergent mixtures for dermal decontamination. Methods: Male Wistar rats were percutaneously treated with sulphur mustard and subjected to wet decontamination 2 min postexposure. Commercially produced detergents NeodekontTM, ArgosTM, DermogelTM and FloraFreeTM were tested for their decontamination efficacy against an exposed group and their protective ratios determined. Results and conclusion: The results showed that all tested detergent solutions produced an increase in the median lethal dose [LD50 = 9.83 (5.87-13.63) mg.kgMINUS SIGN 1] in comparison to controls, which led to increased survival of experimental animals. In general, a

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cutaneous and Ocular Toxicology

ISSN

1556-9527

e-ISSN

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Volume of the periodical

32

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

5

Pages from-to

135-139

UT code for WoS article

000311234500008

EID of the result in the Scopus database

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