Percutaneous toxicity and decontamination of soman, VX, and paraoxon in rats using detegrents
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F13%3A10159528" target="_blank" >RIV/00179906:_____/13:10159528 - isvavai.cz</a>
Result on the web
<a href="http://www.degruyter.com/view/j/aiht.2013.64.issue-2/10004-1254-64-2013-2290/10004-1254-64-2013-2290.xml" target="_blank" >http://www.degruyter.com/view/j/aiht.2013.64.issue-2/10004-1254-64-2013-2290/10004-1254-64-2013-2290.xml</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2478/10004-1254-64-2013-2290" target="_blank" >10.2478/10004-1254-64-2013-2290</a>
Alternative languages
Result language
angličtina
Original language name
Percutaneous toxicity and decontamination of soman, VX, and paraoxon in rats using detegrents
Original language description
Highly toxic organophosphorus compounds (OPs) were originally developed for warfare or as agricultural pesticides. Today, OPs represent a serious threat to military personnel and civilians. This study investigates the in vivo decontamination of male Wistar rats percutaneously exposed to paraoxon and two potent nerve agents - soman (GD) and VX. Four commercial detergents were tested as decontaminants -Neodekont (TM), Argos (TM) Dermogel (TM), and FloraFree (TM). Decontamination performed 2 min after exposure resulted in a higher survival rate in comparison with non-decontaminated controls. The decontamination effectiveness was expressed as protective ratio (PR, median lethal dose of agent in decontaminated animals divided by the median lethal dose of agent in untreated animals). The highest decontamination effectiveness was consistently achieved with Argos (TM) (PR=2.3 to 64.8), followed by Dermogel (TM) (PR=2.4 to 46.1). Neodekont (TM) and FloraFree (TM) provided the lowest decontamina
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
KA - Militarism
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Arhiv za Higijenu Rada i Toksikologiju
ISSN
0004-1254
e-ISSN
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Volume of the periodical
64
Issue of the periodical within the volume
2
Country of publishing house
CR - COSTA RICA
Number of pages
7
Pages from-to
211-217
UT code for WoS article
000321168600003
EID of the result in the Scopus database
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