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In vivo decontamination of the nerve agent VX using the domestic swine model

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F12%3A43870963" target="_blank" >RIV/62157124:16170/12:43870963 - isvavai.cz</a>

  • Alternative codes found

    RIV/60162694:G44__/12:43874670

  • Result on the web

    <a href="http://dx.doi.org/10.3109/15563650.2012.720986" target="_blank" >http://dx.doi.org/10.3109/15563650.2012.720986</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3109/15563650.2012.720986" target="_blank" >10.3109/15563650.2012.720986</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    In vivo decontamination of the nerve agent VX using the domestic swine model

  • Original language description

    The purpose of this in vivo study was to assess a new, putatively optimised method for mass casualty decontamination ("ORCHIDS protocol") for effectiveness in removing the chemical warfare agent VX from the skin of anaesthetised, domestic white pigs. ORCHIDS protocol consists of a 1.5-minute shower with a mild detergent (ArgosTM) supplemented by physical removal. A standard method of wet decontamination was used for comparison. Experimental animals were divided into four groups (A-D). Two groups were exposed to a supra-lethal percutaneous dose (5 x LD(50); 300 mýg kg(-1)) of VX for 1 h prior to decontamination with either the ORCHIDS (C) or standard protocol (D). A third (B, positive control) group was exposed but not subject to decontamination. Blankcontrols (A) received anaesthesia and the corresponding dose of normal saline instead of VX. Observations of the clinical signs of intoxication were supplemented by measurements of whole blood cholinesterase (ChE) performed on samples of

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    GJ - Diseases and animal vermin, veterinary medicine

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/OVUOFVZ200803" target="_blank" >OVUOFVZ200803: Development of novel decontaminants and disinfectants of skin based on micellar compounds</a><br>

  • Continuities

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Clinical toxicology

  • ISSN

    1556-3650

  • e-ISSN

  • Volume of the periodical

    50

  • Issue of the periodical within the volume

    9

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    5

  • Pages from-to

    807-811

  • UT code for WoS article

    000310006900003

  • EID of the result in the Scopus database