In vivo decontamination of the nerve agent VX using the domestic swine model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F12%3A43870963" target="_blank" >RIV/62157124:16170/12:43870963 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/12:43874670
Result on the web
<a href="http://dx.doi.org/10.3109/15563650.2012.720986" target="_blank" >http://dx.doi.org/10.3109/15563650.2012.720986</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/15563650.2012.720986" target="_blank" >10.3109/15563650.2012.720986</a>
Alternative languages
Result language
angličtina
Original language name
In vivo decontamination of the nerve agent VX using the domestic swine model
Original language description
The purpose of this in vivo study was to assess a new, putatively optimised method for mass casualty decontamination ("ORCHIDS protocol") for effectiveness in removing the chemical warfare agent VX from the skin of anaesthetised, domestic white pigs. ORCHIDS protocol consists of a 1.5-minute shower with a mild detergent (ArgosTM) supplemented by physical removal. A standard method of wet decontamination was used for comparison. Experimental animals were divided into four groups (A-D). Two groups were exposed to a supra-lethal percutaneous dose (5 x LD(50); 300 mýg kg(-1)) of VX for 1 h prior to decontamination with either the ORCHIDS (C) or standard protocol (D). A third (B, positive control) group was exposed but not subject to decontamination. Blankcontrols (A) received anaesthesia and the corresponding dose of normal saline instead of VX. Observations of the clinical signs of intoxication were supplemented by measurements of whole blood cholinesterase (ChE) performed on samples of
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
GJ - Diseases and animal vermin, veterinary medicine
OECD FORD branch
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Result continuities
Project
<a href="/en/project/OVUOFVZ200803" target="_blank" >OVUOFVZ200803: Development of novel decontaminants and disinfectants of skin based on micellar compounds</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical toxicology
ISSN
1556-3650
e-ISSN
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Volume of the periodical
50
Issue of the periodical within the volume
9
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
807-811
UT code for WoS article
000310006900003
EID of the result in the Scopus database
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