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The anticancer activity of alpha-tomatine against mammary adenocarcinoma in mice

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F13%3A10188907" target="_blank" >RIV/00179906:_____/13:10188907 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11150/13:10188907

  • Result on the web

    <a href="http://dx.doi.org/10.5507/bp.2013.031" target="_blank" >http://dx.doi.org/10.5507/bp.2013.031</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.5507/bp.2013.031" target="_blank" >10.5507/bp.2013.031</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The anticancer activity of alpha-tomatine against mammary adenocarcinoma in mice

  • Original language description

    Aim. To evaluate the anticancer effect of alpha-tomatine (i.p.) either alone or in combination with doxorubicin (i.v.) in a mouse tumour model. Methods. We studied the effect of repeated alpha-tomatine (0.1 - 9 mg/kg) and/or doxorubicin (2 mg/kg) on thegrowth and mitotic activity of the solid Ehrlich tumour in vivo, as well as on the survival of the tumour-bearing mice. Results. Monotherapy with alpha-tomatine had a significant dose-dependent anticancer effect which peaked at 1 mg/kg. This was shown byboth slowed tumour growth and reduced tumour cell proliferation. We also provide the first evidence that the combination alpha-tomatine (1 mg/kg) and doxorubicin (2 mg/kg) had a synergistic effect and significantly prolonged the survival of the mice. Neither alpha-tomatine nor doxorubicin influenced the infiltration of tumours with CD3+ lymphocytes; nor were we able to find an in vivo modulation of the key molecules of two regulatory pathways reported in vitro as the principal anti-canc

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GPP303%2F12%2FP536" target="_blank" >GPP303/12/P536: The Use of Tomatine, a Tomato Alkaloid, in the Therapy of Cancer</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Biomedical Papers

  • ISSN

    1213-8118

  • e-ISSN

  • Volume of the periodical

    157

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    9

  • Pages from-to

    153-161

  • UT code for WoS article

    000321737100008

  • EID of the result in the Scopus database