Hypermethylation of RAD51L3 and XRCC2 Genes to Predict Late Toxicity in Chemoradiotherapy-Treated Cervical Cancer Patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F13%3A10195436" target="_blank" >RIV/00179906:_____/13:10195436 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/13:10195436

Result on the web

<a href="http://fb.cuni.cz/file/5707/FB2013A0034.pdf" target="_blank" >http://fb.cuni.cz/file/5707/FB2013A0034.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Hypermethylation of RAD51L3 and XRCC2 Genes to Predict Late Toxicity in Chemoradiotherapy-Treated Cervical Cancer Patients

Original language description

Cervical cancer affects women worldwide, especially in developing countries. Approximately 500,000 cases of this disease are diagnosed per year. The method of choice in the treatment of advanced cervical cancers (in accordance with the International Federation of Gynecology and Obstetrics staging system (FIGO) starting from stage JIB) is combined radiotherapy with concomitant chemotherapy. This treatment provides good tumour control, but it carries a risk of late complications in the irradiated area in10-15 A of cases. Methylation is one of the methods of epigenetic control, which has an important role in gene expression. Aberrant methylation of normal CpG islands in promoters of tumour suppressor genes such as RB, p53 or DNA reparation genes ATM, BRCA1,2, and RAD51 gene family causes silencing of their function and cell cycle deregulation, which is one of the efficient ways of neoplastic transformation. The significantly decreased expression of molecules involved in DNA response may

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/NT11334" target="_blank" >NT11334: Genetic prediction of late toxicity of radiotherapy for cervical cancer</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Folia Biologica

ISSN

0015-5500

e-ISSN

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Volume of the periodical

59

Issue of the periodical within the volume

6

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

240-245

UT code for WoS article

000330161600005

EID of the result in the Scopus database

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