Elevated levels of circulating biomarkers of cell death (nucleosomes) in the patients with plaque psoriasis treated with the Goeckerman regimen
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10210375" target="_blank" >RIV/00179906:_____/14:10210375 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/14:10210375
Result on the web
<a href="http://dx.doi.org/10.4149/BLL_2014_047" target="_blank" >http://dx.doi.org/10.4149/BLL_2014_047</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/BLL_2014_047" target="_blank" >10.4149/BLL_2014_047</a>
Alternative languages
Result language
angličtina
Original language name
Elevated levels of circulating biomarkers of cell death (nucleosomes) in the patients with plaque psoriasis treated with the Goeckerman regimen
Original language description
Nucleosomes are complexes that are formed during apoptosis. Psoriasis is a chronic skin disease characterized by keratinocyte hyperproliferation and anti-apoptotic features. Presented study was focused to expression of circulating biomarkers of cell death (circulating nucleosomes, CN) during Goeckerman therapy of psoriasis (UV, PAHs). We found slightly (but statistically significant) elevated level of circulating biomarkers of cell death (nucleosomes) in patients with plaque psoriasis treated with GR (PAHs, UV radiation). We suppose that elevated level of CN is a result of combination of the positive effects of GR and its weak genotoxic effect (mainly PAHs). Conclusions are supported by significant correlation between CN and urinary level of 1-OHP after GR and significantly elevated level of CA after GR.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FM - Hygiene
OECD FORD branch
—
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bratislavské lekárske listy
ISSN
0006-9248
e-ISSN
—
Volume of the periodical
115
Issue of the periodical within the volume
4
Country of publishing house
SK - SLOVAKIA
Number of pages
4
Pages from-to
229-232
UT code for WoS article
000335542500008
EID of the result in the Scopus database
—