Changes in circulating cell-free DNA and nucleosomes in patients with exacerbated psoriasis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F17%3A10364864" target="_blank" >RIV/00216208:11150/17:10364864 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11160/17:10364864 RIV/00179906:_____/17:10364864

Result on the web

<a href="http://link.springer.com/article/10.1007/s00403-017-1785-5" target="_blank" >http://link.springer.com/article/10.1007/s00403-017-1785-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00403-017-1785-5" target="_blank" >10.1007/s00403-017-1785-5</a>

Result language

angličtina

Original language name

Changes in circulating cell-free DNA and nucleosomes in patients with exacerbated psoriasis

Original language description

Psoriasis is a multifactorial chronic inflammatory disease. We aimed to examine blood levels of nucleosomes derived from apoptotic cells, nucleosomal cell-free DNA (cfDNA) and immune-inflammatory biomarkers tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin 6 (IL-6) in psoriatic subjects. The study included 28 patients with exacerbated psoriasis vulgaris and 22 controls. The clinical and laboratory investigations included the determination of PASI score, BMI, cfDNA (by real-time PCR), nucleosomes, TNF-alpha, CRP, and IL-6. The range of PASI score in psoriatic patients was 10-34 (median 19). In the patients, we found significantly elevated levels (p &lt; 0.001) of cfDNA, nucleosomes, TNF-alpha, CRP, and IL-6. We did not find any significant relationship between the analyzed parameters in either group (i.e., experimental or control). Elevated levels of the biomarkers of inflammation (TNF-alpha, CRP, and IL-6) and the indicators of apoptosis (cfDNA, circulating nucleosomes) proved that exacerbated psoriasis vulgaris is associated with a high degree of systemic inflammatory responses and dysregulated apoptotic pathways.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Archives of Dermatological Research

ISSN

0340-3696

e-ISSN

—

Volume of the periodical

309

Issue of the periodical within the volume

10

Country of publishing house

DE - GERMANY

Number of pages

7

Pages from-to

815-821

UT code for WoS article

000414651400005

EID of the result in the Scopus database

2-s2.0-85031398768