Oxidative stress-mediated cytotoxicity and metabolism of T-2 toxin and deoxynivalenol in animals and humans: an update

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10218438" target="_blank" >RIV/00179906:_____/14:10218438 - isvavai.cz</a>

Alternative codes found

RIV/62690094:18450/14:50002387 RIV/62690094:18470/14:50002387

Result on the web

<a href="http://link.springer.com/article/10.1007%2Fs00204-014-1280-0" target="_blank" >http://link.springer.com/article/10.1007%2Fs00204-014-1280-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00204-014-1280-0" target="_blank" >10.1007/s00204-014-1280-0</a>

Result language

angličtina

Original language name

Oxidative stress-mediated cytotoxicity and metabolism of T-2 toxin and deoxynivalenol in animals and humans: an update

Original language description

Trichothecenes are a large family of structurally related toxins mainly produced by Fusarium genus. Among the trichothecenes, T-2 toxin and deoxynivalenol (DON) cause the most concern due to their wide distribution and highly toxic nature. Trichothecenesare known for their inhibitory effect on eukaryotic protein synthesis, and oxidative stress is one of their most important underlying toxic mechanisms. They are able to generate free radicals, including reactive oxygen species, which induce lipid peroxidation leading to changes in membrane integrity, cellular redox signaling, and in the antioxidant status of the cells. The mitogen-activated protein kinases signaling pathway is induced by oxidative stress, which also induces caspase-mediated cellular apoptosis pathways. Several new metabolites and novel metabolic pathways of T-2 toxin have been discovered very recently. In human cell lines, HT-2 and neosolaniol (NEO) are the major metabolites of T-2 toxin. Hydroxylation on C-7 and C-9 a

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Archives of Toxicology

ISSN

0340-5761

e-ISSN

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Volume of the periodical

88

Issue of the periodical within the volume

7

Country of publishing house

DE - GERMANY

Number of pages

18

Pages from-to

1309-1326

UT code for WoS article

000338283400003

EID of the result in the Scopus database

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