Retention behavior of pyridinium oximes on PFP stationary phase in high-performance liquid chromatography

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10227211" target="_blank" >RIV/00179906:_____/14:10227211 - isvavai.cz</a>
Alternative codes found
RIV/62690094:18470/14:50002315 RIV/60162694:G44__/14:43874792
Result on the web
<a href="http://chromsci.oxfordjournals.org/content/52/3/246.full.pdf+html" target="_blank" >http://chromsci.oxfordjournals.org/content/52/3/246.full.pdf+html</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/chromsci/bmt019" target="_blank" >10.1093/chromsci/bmt019</a>

Result language
angličtina
Original language name
Retention behavior of pyridinium oximes on PFP stationary phase in high-performance liquid chromatography
Original language description
The chromatographic behavior was studied of a series of potential acetylcholinesterase reactivators, pyridinium oximes, bearing linear aliphatic chains of the length of the aliphatic bridge from 1 to 12 carbon atoms, on a pentafluorophenyl-modified stationary phase. The retention mechanisms and the dependence of the capacity factor on mobile phase composition, aliphatic chain bridge length and calculated log P were evaluated and discussed in detail. The separation of the studied oximes was found to be driven by hydrophobic interactions when a lower content of organic modifier was used in mobile phase; however, the ion-exchange mechanism was the leading one when a large portion of organic modifier was used. In addition, the lipophilicity was found to bea driving mechanism of the separation of oximes bearing a connecting chain of the length of 6-12 carbon atoms, whereas the retention of oximes with shorter connecting chains was significantly influenced by other separation mechanisms suc
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Project
<a href="/en/project/NT12062" target="_blank" >NT12062: Preparation and biological evaluation of new therapeutics against to pesticides</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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