In Vivo Evaluation of Cholinesterase Activity, Oxidative Stress Markers, Cyto- and Genotoxicity of K048 Oxime - a Promising Antidote against Organophosphate Poisoning

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10272061" target="_blank" >RIV/00179906:_____/14:10272061 - isvavai.cz</a>

Alternative codes found

RIV/62690094:18470/14:50002291

Result on the web

<a href="http://dx.doi.org/10.1111/bcpt.12158" target="_blank" >http://dx.doi.org/10.1111/bcpt.12158</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/bcpt.12158" target="_blank" >10.1111/bcpt.12158</a>

Result language

angličtina

Original language name

In Vivo Evaluation of Cholinesterase Activity, Oxidative Stress Markers, Cyto- and Genotoxicity of K048 Oxime - a Promising Antidote against Organophosphate Poisoning

Original language description

K048 is a member of K-oximes, a new oxime class that has recently been confirmed effective against poisoning by the nerve agent tabun and several pesticides. The toxicity profile of the K048 oxime has not been fully characterized and its optimal therapeutic dose has not yet been established. Earlier studies report excellent results with K048 in reactivating tabun-phosphorylated AChE and in the therapy of tabun-poisoned mice. It possesses a low acute toxicity and exerts an acceptable toxicity profile onisolated human peripheral blood lymphocytes in vitro. Intraperitoneal administration of K048 in rats resulted in an LD50 of 238.3mg/kg. In this in vivo study, we investigated cholinesterase (ChE) activity and oxidative stress marker levels (lipid peroxidation and superoxide dismutase activity) in the plasma of exposed rats after administering the compound at 25% of its LD50. Lymphocyte viability was evaluated using an acridine orange/ethidium bromide in situ fluorescent assay. The levels

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

—

Project

<a href="/en/project/LH13009" target="_blank" >LH13009: The research of modified cholinesterase reactivators for organophosphorus pesticide poisoning treatment</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Basic and Clinical Pharmacology and Toxicology

ISSN

1742-7835

e-ISSN

—

Volume of the periodical

114

Issue of the periodical within the volume

4

Country of publishing house

DK - DENMARK

Number of pages

8

Pages from-to

344-351

UT code for WoS article

000332208300008

EID of the result in the Scopus database

—