Effects of Oxime K203 and Oxidative Stress in Plasma of Tabun Poisoned Rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13440%2F12%3A43884027" target="_blank" >RIV/44555601:13440/12:43884027 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/12:43874587
Result on the web
<a href="http://dx.doi.org/10.5562/cca1811" target="_blank" >http://dx.doi.org/10.5562/cca1811</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5562/cca1811" target="_blank" >10.5562/cca1811</a>
Alternative languages
Result language
angličtina
Original language name
Effects of Oxime K203 and Oxidative Stress in Plasma of Tabun Poisoned Rats
Original language description
The highly toxic nature of tabun has been known for many years, but there are still serious limitations to antidotal therapy. In this study, we used rats as an experimental model to evaluate the efficiency of bispyridinium para-oxime 1(203 as therapy against tabun poisoning as well as to examine if induction of oxidative stress is linked to organophosphate toxicity. 1(203 showed high potency in counteracting tabun poisoning. Either alone or in combination with atropine, this oxime significantly increased cholinesterase activity at 0.5 and 1 h compared to untreated rats poisoned with tabun. Simultaneous measurements of markers of oxidative stress (lipid peroxidation and superoxide dismutase) showed that tabun poisoning, but also therapy (oxime alone oroxime plus atropine) applied immediately after tabun poisoning, could generate free radical species that may cause oxidative stress in rats.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GP305%2F07%2FP162" target="_blank" >GP305/07/P162: Relationship between structure of acetylcholinesterase reactivators and their reactivation potency</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Croatica Chemica Acta
ISSN
0011-1643
e-ISSN
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Volume of the periodical
85
Issue of the periodical within the volume
2
Country of publishing house
HR - CROATIA
Number of pages
7
Pages from-to
193-199
UT code for WoS article
000306880200010
EID of the result in the Scopus database
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