Deferoxamine but not dexrazoxane alleviates liver injury induced by endotoxemia in rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10272499" target="_blank" >RIV/00179906:_____/14:10272499 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/14:10272499 RIV/00216208:11160/14:10272499
Result on the web
<a href="http://journals.lww.com/shockjournal/Fulltext/2014/10000/Deferoxamine_but_not_Dexrazoxane_Alleviates_Liver.13.aspx" target="_blank" >http://journals.lww.com/shockjournal/Fulltext/2014/10000/Deferoxamine_but_not_Dexrazoxane_Alleviates_Liver.13.aspx</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/SHK.0000000000000210" target="_blank" >10.1097/SHK.0000000000000210</a>
Alternative languages
Result language
angličtina
Original language name
Deferoxamine but not dexrazoxane alleviates liver injury induced by endotoxemia in rats
Original language description
The purpose of the present study was to compare the activity of two different clinically available iron chelators on the development of acute liver injury after administration of the bacterial endotoxin (lipopolysaccharide [LPS]) in rats. Lipopolysaccharide was administered either alone or after pretreatment with dexrazoxane (DEX) or deferoxamine (DFO). Control groups received only saline or its combination with either chelator. After 8 h, untreated LPS rats developed liver injury, with signs of inflammation and oxidative stress. Lipopolysaccharide reduced plasma iron concentrations in association with increased production of hepcidin and the reduced liver expression of ferroportin. Administration of chelating agents to LPS animals showed distinct effects. Although both drugs were able to reduce liver iron content, together with corresponding changes in hepcidin and ferroportin expressions, only DFO showed a protective effect against liver injury despite relatively small liver concentr
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Shock
ISSN
1073-2322
e-ISSN
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Volume of the periodical
42
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
372-379
UT code for WoS article
000342465100013
EID of the result in the Scopus database
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