Modification of hepatic iron metabolism induced by pravastatin during obstructive cholestasis in rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F11%3A10099490" target="_blank" >RIV/00216208:11150/11:10099490 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/11:10099490
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0024320511004243" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0024320511004243</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.lfs.2011.08.014" target="_blank" >10.1016/j.lfs.2011.08.014</a>
Alternative languages
Result language
angličtina
Original language name
Modification of hepatic iron metabolism induced by pravastatin during obstructive cholestasis in rats
Original language description
The aim of the study was to evaluate iron biochemistry and contributing liver mechanisms during obstructive cholestasis and pravastatin treatment in rats. A rat model of cholestasis induced by bile duct ligation (BDL) was used for the study. The administration of pravastatin to BDL animals attenuated proliferation changes in liver parenchyma, prevented HO-1 induction, restored hepatic mRNA hepcidin expression to control levels and induced the mRNA expression of ferritin, transferrin receptors (TfR1/2) and divalent metal transporter-1. This was accompanied by an increased content of intrahepatic iron when compared to the BDL animals, and a reduction of hyperbilirubinemia. In conclusion, cholestasis-induced increase in plasma and decrease in hepatic ironlevels were associated with up-regulation of liver HO-1 and ferroportin 1. Pravastatin alleviated cholestatic liver impairment and raised liver iron content by modulation of heme catabolism and an increase of hepatic iron uptake and stor
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Life Sciences
ISSN
0024-3205
e-ISSN
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Volume of the periodical
89
Issue of the periodical within the volume
19
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
717-724
UT code for WoS article
000296311800007
EID of the result in the Scopus database
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