Pravastatin modulates liver bile acid and cholesterol homeostasis in rats with chronic cholestasis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F11%3A10099491" target="_blank" >RIV/00216208:11150/11:10099491 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/11:10099491 RIV/00179906:_____/11:10099491
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1746.2011.06748.x/pdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1746.2011.06748.x/pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/j.1440-1746.2011.06748.x" target="_blank" >10.1111/j.1440-1746.2011.06748.x</a>
Alternative languages
Result language
angličtina
Original language name
Pravastatin modulates liver bile acid and cholesterol homeostasis in rats with chronic cholestasis
Original language description
The administration of pravastatin to patients with cholestatic liver disease has suggested the potential of the drug with regard to reducing raised plasma cholesterol and bile acid levels. Information about the mechanisms associated with this effect is lacking. Thus, the aim of this study was to evaluate pravastatin effects on the liver bile acid and cholesterol homeostasis in healthy and cholestatic rats. Control sham-operated and reversibly bile duct-obstructed (BDO) rats were treated with pravastatin(1 or 5 mg/kg) or the vehicle alone for 7 days after surgery. Results of the study demonstrated that pravastatin rendered a positive reduction in BDO-induced increases in plasma bile acid concentrations and cholesterol liver content, mainly through thetranscriptionally-mediated down-regulation of genes involved in the synthesis of these compounds in the liver.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NS9739" target="_blank" >NS9739: Can Statins Attenuate a development of cholestatic liver disease?</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Gastroenterology and Hepatology
ISSN
0815-9319
e-ISSN
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Volume of the periodical
26
Issue of the periodical within the volume
10
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
1544-1551
UT code for WoS article
000295134800014
EID of the result in the Scopus database
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