Bile acids decrease intracellular bilirubin levels in the cholestatic liver: implications for bile acid-mediated oxidative stress
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F11%3A9679" target="_blank" >RIV/00064165:_____/11:9679 - isvavai.cz</a>
Alternative codes found
RIV/00023001:_____/11:00002512 RIV/00216208:11110/11:9679
Result on the web
<a href="http://dx.doi.org/10.1111/j.1582-4934.2010.01098.x" target="_blank" >http://dx.doi.org/10.1111/j.1582-4934.2010.01098.x</a>
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Bile acids decrease intracellular bilirubin levels in the cholestatic liver: implications for bile acid-mediated oxidative stress
Original language description
High plasma concentrations of bile acids (BA) and bilirubin are hallmarks of cholestasis. BA are implicated in the pathogenesis of cholestatic liver damage through mechanisms involving oxidative stress, whereas bilirubin is a strong antioxidant. We evaluated the roles of bilirubin and BA on mediating oxidative stress in rats following bile duct ligation (BDL). Adult female Wistar and Gunn rats intraperitoneally anaesthetized with ketamine and xylazine underwent BDL or sham operation. Cholestatic markers, antioxidant capacity, lipid peroxidation and heme oxygenase (HO) activity were determined in plasma and/or liver tissue 5 days after surgery. HepG2-rNtcp cells were used for in vitro experiments. Plasma bilirubin levels in control and BDL animals positively correlated with plasma antioxidant capacity. Peroxyl radical scavenging capacity was significantly higher in the plasma of BDL Wistar rats (210 +/- 12%, P < 0.0001) compared to controls, but not in the liver tissues. Furthermore aft
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/NR9366" target="_blank" >NR9366: The role of heme catabolic pathway in in the pathogenesis of cholestasis</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Cellular and Molecular Medicine
ISSN
1582-1838
e-ISSN
—
Volume of the periodical
15
Issue of the periodical within the volume
5
Country of publishing house
RO - ROMANIA
Number of pages
10
Pages from-to
1156-1165
UT code for WoS article
000291045800015
EID of the result in the Scopus database
—