The effect of topiramate and lamotrigine on rat bone mass, structure and metabolism

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10281116" target="_blank" >RIV/00179906:_____/14:10281116 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/14:10281116

Result on the web

<a href="http://dx.doi.org/10.1016/j.jns.2014.02.032" target="_blank" >http://dx.doi.org/10.1016/j.jns.2014.02.032</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jns.2014.02.032" target="_blank" >10.1016/j.jns.2014.02.032</a>

Result language

angličtina

Original language name

The effect of topiramate and lamotrigine on rat bone mass, structure and metabolism

Original language description

There is only limited data concerning the effect of the newer antiepileptic drugs on bone. The objective of this study was to determine the effect of topiramate (TPM) and lamotrigine (LTG) monotherapy on bone mineral density (BMD), mineral content (BMC),bone markers, body composition and bone mechanical strength in the orchidectomized (ORX) rat model. 24 orchidectomized Wistar rats were divided into control and test groups, 8 rats in each group. The control rats received standard laboratory diet (SLD)while rats in the test group were fed with SLD enriched with LTG or TPM for 12 weeks. Dual energy X-ray absorptiometry was used to measure bone mineral density. The concentrations of bone metabolism markers were assayed in bone homogenate. In addition, both femurs were measured and used for biomechanical testing. Compared to the control group, both test groups had significantly lower weight, fat mass, whole body and femur BMD, BMC and reduced mechanical strength of bone. All of these cha

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of the Neurological Sciences

ISSN

0022-510X

e-ISSN

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Volume of the periodical

340

Issue of the periodical within the volume

1-2

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

6

Pages from-to

80-85

UT code for WoS article

000336713300014

EID of the result in the Scopus database

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