Effect of Mirtazapine on Rat Bone Tissue after Orchidectomy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F15%3A10306854" target="_blank" >RIV/00216208:11150/15:10306854 - isvavai.cz</a>
Alternative codes found
RIV/00179906:_____/15:10306854
Result on the web
<a href="http://dx.doi.org/10.1159/000380953" target="_blank" >http://dx.doi.org/10.1159/000380953</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1159/000380953" target="_blank" >10.1159/000380953</a>
Alternative languages
Result language
angličtina
Original language name
Effect of Mirtazapine on Rat Bone Tissue after Orchidectomy
Original language description
Objective: Our study aimed to investigate the effect of mirtazapine on bone metabolism in the orchidectomized rat model. Methods: Rats were divided into three groups. A sham-operated control group (SHAM group) and a control group after orchidectomy (ORXgroup) received the standard laboratory diet (SLD). An experimental group after orchidectomy (ORX MIRTA group) received SLD enriched with mirtazapine for 12 weeks. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry. Bone marker concentrations of osteoprotegerin (OPG), amino-terminal propeptide of procollagen type I, bone alkaline phosphatase (BALP), sclerostin and bone morphogenetic protein 2 were examined in bone homogenate. The femurs were used for biomechanical testing. Results: Compared with the control ORX group, we found a lower BMD in the ORX MIRTA group. The differences were statistically significant, although not in the lumbar vertebrae. BMD was lower in the MIRTA group, suggesting a preferential effect
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pharmacology
ISSN
0031-7012
e-ISSN
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Volume of the periodical
95
Issue of the periodical within the volume
3-4
Country of publishing house
CH - SWITZERLAND
Number of pages
7
Pages from-to
166-172
UT code for WoS article
000354663600009
EID of the result in the Scopus database
2-s2.0-84927948479