Negative effect of serotonin-norepinephrine reuptake inhibitor therapy on rat bone tissue after orchidectomy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F15%3A10306859" target="_blank" >RIV/00216208:11150/15:10306859 - isvavai.cz</a>
Alternative codes found
RIV/00179906:_____/15:10306859
Result on the web
<a href="http://dx.doi.org/10.1016/j.ejphar.2015.04.029" target="_blank" >http://dx.doi.org/10.1016/j.ejphar.2015.04.029</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejphar.2015.04.029" target="_blank" >10.1016/j.ejphar.2015.04.029</a>
Alternative languages
Result language
angličtina
Original language name
Negative effect of serotonin-norepinephrine reuptake inhibitor therapy on rat bone tissue after orchidectomy
Original language description
Our goal was to determine if venlafaxine has a negative effect on bone metabolism. Rats were divided into three groups. The sham-operated control group (SHAM), the control group after orchidectomy (ORX), and the experimental group after orchidectomy received venlafaxine (VEN ORX) in standard laboratory diet (SLD) for 12 weeks. Bone mineral content (BMC) was measured by dual energy X-ray absorptiometry (DXA). Bone marker concentrations of carboxy-terminal cross-linking telopeptide of type l collagen (CTX-l), osteoprotegerin (OPG), amino-terminal propeptide of procollagen type l (P1NP), bone alkaline phosphatase (BALP), sclerostin and bone morphogenetic protein 2 (BMP-2) were examined in bone homogenate. The femurs were used for biomechanical testing. Compared to the ORX group we found lower BMD in the diaphysis area of the femur in the VEN ORX group, suggesting a preferential effect on cortical bone. Of the bone metabolism markers, there was significant decrease (ORX control group versu
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
—
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Pharmacology
ISSN
0014-2999
e-ISSN
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Volume of the periodical
761
Issue of the periodical within the volume
August
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
5
Pages from-to
65-69
UT code for WoS article
000359227300008
EID of the result in the Scopus database
2-s2.0-84929093726