Salicylanilide diethyl phosphates: Synthesis, antimicrobial activity and cytotoxicity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10281768" target="_blank" >RIV/00179906:_____/14:10281768 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/14:10281768 RIV/00216208:11160/14:10281768

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S0968089613010109" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0968089613010109</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bmc.2013.12.016" target="_blank" >10.1016/j.bmc.2013.12.016</a>

Result language

angličtina

Original language name

Salicylanilide diethyl phosphates: Synthesis, antimicrobial activity and cytotoxicity

Original language description

A series of 27 salicylanilide diethyl phosphates was prepared as a part of our on-going search for new antimicrobial active drugs. All compounds exhibited in vitro activity against Mycobacterium tuberculosis, Mycobacterium kansasii and Mycobacterium avium strains, with minimum inhibitory concentration (MIC) values of 0.5-62.5 mu mol/L. Selected salicylanilide diethyl phosphates also inhibit multidrug-resistant tuberculous strains at the concentration of 1 mu mol/L. Salicylanilide diethyl phosphates alsoexhibited mostly the activity against Gram-positive bacteria (MICs }= P1.95 mu mol/L), whereas their antifungal activity is significantly lower. The IC50 values for Hep G2 cells were within the range of 1.56-33.82 mu mol/L, but there is no direct correlation with MICs for mycobacteria.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bioorganic and Medicinal Chemistry

ISSN

0968-0896

e-ISSN

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Volume of the periodical

22

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

728-737

UT code for WoS article

000329576400007

EID of the result in the Scopus database

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