Salicylanilide Diethyl Phosphates as Potential Inhibitors of Some Mycobacterial Enzymes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F14%3A10281951" target="_blank" >RIV/00216208:11160/14:10281951 - isvavai.cz</a>
Result on the web
<a href="http://www.hindawi.com/journals/tswj/2014/703053/" target="_blank" >http://www.hindawi.com/journals/tswj/2014/703053/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2014/703053" target="_blank" >10.1155/2014/703053</a>
Alternative languages
Result language
angličtina
Original language name
Salicylanilide Diethyl Phosphates as Potential Inhibitors of Some Mycobacterial Enzymes
Original language description
Antimycobacterially active salicylanilide diethyl phosphates were evaluated to identify their potential drug target(s) for the inhibition of several mycobacterial enzymes, including isocitrate lyase, L-alanine dehydrogenase (MtAlaDH), lysine epsilon-aminotransferase, chorismate mutase, and pantothenate synthetase. The enzymes are related to the nongrowing state of Mycobacterium tuberculosis. Salicylanilide diethyl phosphates represent new candidates with significant inhibitory activity especially against L-alanine dehydrogenase. The most active MtAlaDH inhibitor, 5-chloro-2-[(3-chlorophenyl)carbamoyl]phenyl diethyl phosphate, has an IC50 of 4.96 mu M and the best docking results. Other mycobacterial enzymes were mostly inhibited by some derivatives butat higher concentrations; isocitrate lyase showed the highest resistance to salicylanilide diethyl phosphates.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
The Scientific World Journal
ISSN
1537-744X
e-ISSN
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Volume of the periodical
2014
Issue of the periodical within the volume
November
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
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UT code for WoS article
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EID of the result in the Scopus database
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