Importance of promoter methylation of GATA4 and TP53 genes in endometrioid carcinoma of endometrium
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10282721" target="_blank" >RIV/00179906:_____/14:10282721 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/14:10282721
Result on the web
<a href="http://dx.doi.org/10.1515/cclm-2013-0162" target="_blank" >http://dx.doi.org/10.1515/cclm-2013-0162</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1515/cclm-2013-0162" target="_blank" >10.1515/cclm-2013-0162</a>
Alternative languages
Result language
angličtina
Original language name
Importance of promoter methylation of GATA4 and TP53 genes in endometrioid carcinoma of endometrium
Original language description
Background: Epigenetic changes are considered to be a frequent event during tumor development. Various methylation changes have been identified and show promise as potential cancer biomarkers. The aim of this study was to investigate promoter methylationof GATA4 and TP53 genes in endometrioid carcinoma of endometrium. Methods: To search for promoter methylation of GATA4 and TP53 genes we used methylation-specific PCR (MSP) to compare the methylation status of 54 patients with endometrioid carcinoma ofendometrium and 18 patients with normal endometrial tissue. Results: In our study MSP revealed GATA4 promoter methylation in 44 of 54 in the carcinoma group (81.5%), and in none of the control group. No methylation was observed in TP53 gene. Conclusions:In conclusion, our study showed that there is significantly higher methylation in GATA4 gene in the endometrial cancer group compared with samples of nonneoplastic endometrium. The finding suggests the importance of hypermethylation of t
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical Chemistry and Laboratory Medicine
ISSN
1434-6621
e-ISSN
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Volume of the periodical
52
Issue of the periodical within the volume
8
Country of publishing house
DE - GERMANY
Number of pages
6
Pages from-to
1229-1234
UT code for WoS article
000340786100026
EID of the result in the Scopus database
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