HI-6 oxime (an acetylcholinesterase reactivator): blood plasma pharmacokinetics and organ distribution in experimental pigs

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10283810" target="_blank" >RIV/00179906:_____/14:10283810 - isvavai.cz</a>

Alternative codes found

RIV/60162694:G44__/14:43875352 RIV/00216208:11150/14:10283810

Result on the web

<a href="http://www.nel.edu/archive_issues/o/35_s2/35_s2_Kunes_186-191.pdf" target="_blank" >http://www.nel.edu/archive_issues/o/35_s2/35_s2_Kunes_186-191.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

HI-6 oxime (an acetylcholinesterase reactivator): blood plasma pharmacokinetics and organ distribution in experimental pigs

Original language description

Oxime HI-6 DMS (dimethanesulfonate) is an asymmetric bispyridinium aldoxime and essential acetylcholinesterase (AChE) reactivator. The high effectiveness is due to its wide spectrum of therapeutic activity against different structures of nerve agents. Aim of this study was to compare plasma time profiles and tissue distribution (to delimitation of potential toxicity risks) after its intramuscular (i.m.) and intragastric (i.g.) administration to experimental pigs. The study entered female Landrace pigs (Sus scrofa f. domestica), 4-5 months old animals, 29+-3.2 kg of body weight. Before the HI-6 DMS administration (i.m. injection or i.g. using a gastric tube), vena auricularis was cannulated (under general anaesthesia) for collection of blood samples. The tissue distribution study was carried out at expected t-max. Concentrations of HI-6 DMS in blood plasma and other tissue samples were detected by means of HPLC method. Fast absorption after i.m. administration, relatively slow absorptio

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

<a href="/en/project/NT14270" target="_blank" >NT14270: Pharmacokinetics and gastrointestinal motor effects of novel acetylcholinesterase modulators in experimental pigs</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

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Volume of the periodical

35

Issue of the periodical within the volume

Suppl. 2

Country of publishing house

SE - SWEDEN

Number of pages

6

Pages from-to

186-191

UT code for WoS article

000351064900025

EID of the result in the Scopus database

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