Hyaluronidase: Its effects on HI-6 dichloride and dimethanesulphonate pharmacokinetic profile in pigs

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F13%3A10146026" target="_blank" >RIV/00179906:_____/13:10146026 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/13:10146026 RIV/60162694:G44__/13:43874788

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S0378427413001689" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0378427413001689</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.toxlet.2013.04.013" target="_blank" >10.1016/j.toxlet.2013.04.013</a>

Result language

angličtina

Original language name

Hyaluronidase: Its effects on HI-6 dichloride and dimethanesulphonate pharmacokinetic profile in pigs

Original language description

Pigs were administered intramuscularly molar equivalents of HI-6 salts (HI-6 dichloride 10.71 mg/kg and HI-6 DMS 13.59 mg/kg) either with or without hyaluronidase (60 U/kg). Hyaluronidase is supposed to increase tissue permeability and diminishes discomfort caused by the intramuscular injection. Doses of HI-6 salts corresponded with standard HI-6 dichloride dose in one autoinjector (500 mg) and were recalculated for 1 kg of body weight. According to the results, both HI-6 salts applied in combination with hyaluronidase had increased tissue absorption and improved pharmacokinetic profile. The Cmax was significantly higher in case of HI-6 DMS plus hyaluronidase (29.6 +- 2.98 ?g/ml) administration increase compared to HI-6 DMS (23.8 +- 3.04 ?g/ml) and HI-6 dichloride (19.0 +- 0.93 ?g/ml); both without hyaluronidase. Bioavailability calculated as AUCtotal (HI-6 DMS with hyaluronidase, 4119 +- 647 min ?g/ml) was also significantly higher compared to HI-6 DMS (2259 +- 329 min ?g/ml) and HI-6

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

<a href="/en/project/NT12062" target="_blank" >NT12062: Preparation and biological evaluation of new therapeutics against to pesticides</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Toxicology Letters

ISSN

0378-4274

e-ISSN

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Volume of the periodical

220

Issue of the periodical within the volume

2

Country of publishing house

IE - IRELAND

Number of pages

5

Pages from-to

167-171

UT code for WoS article

000320595100009

EID of the result in the Scopus database

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