Normal karyotype is a poor prognostic factor in myeloid leukemia of Down syndrome: a retrospective, international study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10285027" target="_blank" >RIV/00179906:_____/14:10285027 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.3324/haematol.2013.089425" target="_blank" >http://dx.doi.org/10.3324/haematol.2013.089425</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3324/haematol.2013.089425" target="_blank" >10.3324/haematol.2013.089425</a>

Result language

angličtina

Original language name

Normal karyotype is a poor prognostic factor in myeloid leukemia of Down syndrome: a retrospective, international study

Original language description

Myeloid leukemia of Down syndrome has a better prognosis than sporadic pediatric acute myeloid leukemia. Most cases of myeloid leukemia of Down syndrome are characterized by additional cytogenetic changes besides the constitutional trisomy 21, but theirpotential prognostic impact is not known. We, therefore, conducted an international retrospective study of clinical characteristics, cytogenetics, treatment, and outcome of 451 children with myeloid leukemia of Down syndrome. All karyotypes were centrally reviewed before assigning patients to subgroups. The overall 7-year event-free survival for the entire cohort was 78% (+/- 2%), with the overall survival rate being 79% (+/- 2%), the cumulative incidence of relapse 12% (+/- 2%), and the cumulative incidence of toxic death 7% (+/- 1%). Outcome estimates showed large differences across the different cytogenetic subgroups. Based on the cumulative incidence of relapse, we could risk-stratify patients into two groups: cases with a normal ka

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Haematologica

ISSN

0390-6078

e-ISSN

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Volume of the periodical

99

Issue of the periodical within the volume

2

Country of publishing house

IT - ITALY

Number of pages

9

Pages from-to

299-307

UT code for WoS article

000336253900022

EID of the result in the Scopus database

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