Formulation of cores for the controlled release of glucose for prevention of hypoglycemia in diabetes patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10286237" target="_blank" >RIV/00179906:_____/14:10286237 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16370/14:43873123

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Formulation of cores for the controlled release of glucose for prevention of hypoglycemia in diabetes patients

Original language description

Hypoglycemic episodes are a frequent and serious complication in both types of diabetes mellitus. The risk of hypoglycemic conditions can be managed by a coated pellet dosage form, which can release glucose in a delayed regime to achieve the maximum estimated effect of antidiabetics. The pellet cores, intended for coating with ethylcellulose, were prepared consisting of four osmotically active excipients: crosscarmellose (Ac-Di-Sol(R)), a mixture of microcrystalline cellulose and carmellose sodium (Avicel(R) RC 591), carboxymethyl starch sodium (Vivastar(R) P 5000) and macrogol 6000, respectively. The aim of this study was to increase the glucose content in the pellets to minimize their volume and to improve the administration to the patients. The content of glucose in the pellet cores was increased from 45 to 75 or 80%, respectively, for all compositions. All pellet samples had satisfactory mechanical and flow properties required for the coating process. The highest values of spherici

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

<a href="/en/project/NT14479" target="_blank" >NT14479: Preparation of dosage forms with controlled release of glucose to prevention of hypoglycemic states.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Česká a slovenská farmacie

ISSN

1210-7816

e-ISSN

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Volume of the periodical

63

Issue of the periodical within the volume

5

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

206-212

UT code for WoS article

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EID of the result in the Scopus database

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